In the Name of Allah, the Most Gracious, the Most Merciful.
The Qur'an is a Revelation from Allah and the Universe is His True Creation
Allah informs that He has revealed the Book to His servant and Messenger Muhammad -- may Allah's blessings be upon him until the Day of Judgement. Allah then describes Himself as being of unimaginable glory, possessing ultimate wisdom in His statements and actions. Allah then says,
قُلْ أَرَأَيْتُم مَّا تَدْعُونَ مِن دُونِ اللَّـهِ (Say, "Tell me about those whom you invoke instead of Allah,...46:4) In these verses, the claim of the polytheists about the existence of some other gods has been refuted by demanding a proof to substantiate this claim, because no claim can be accepted, neither rationally nor according to the religious principles, unless it is proved by concrete evidences to support it. Then dealing with all possible types of arguments, it has been proved that they do not have any evidence or proof in their favor, and that their insisting on such a baseless claim is nothing but deviation from the truth. The arguments have been classified by these verses in three types. One is a rational argument. Verse 4 negates any argument of this type in their favor by saying, أَرُونِي مَاذَا خَلَقُوا مِنَ الْأَرْضِ أَمْ لَهُمْ شِرْكٌ فِي السَّمَاوَاتِ "Show me what they have created of the earth; Or have they a share in (the creation of the heavens?" (46:4)
Knowledge is in fact of two types: revealed and established. The former reached man through the prophets, while the latter was established as such by means of research and experiments carried out by human beings. Neither of these two types of knowledge indicates that there is any being worthy of worship except the one and only God. When neither supports the concept of polytheism, how can a polytheistic credo be appropriate for man? One who seeks the support of any thing or any being other than God, will find himself abandoned by that thing or being in the Hereafter.
Uthmani text of the Madinah mushaf (King Fahd Complex). Translation: Saheeh International. Tafsir via Quran.com.