(Say: "O you mankind! If you are in doubt as to my religion, then (know that) I will never worship those whom you worship besides Allah. But I worship Allah Who causes you to die.) (10:104) The fact that the word "Rabb" (Lord) is connected to the word city (in the phrase "the Lord of this city") is a sign of honor and divine care for that city. This is like the Ayah,
رَبَّ هَـٰذِهِ الْبَلْدَةِ (the Lord of this city - 27:91). Majority of the commentators have taken the word o=ff "Baldah" (the city) for Makkah. Allah Ta’ ala is the Lord of all the worlds and the Lord of heavens and earth. Therefore, the particular mention of Makkah here is to show its revered splendor, and its respect and honour in the sight of Allah Ta a1a. Word Haram is derived from Tahrim, which means "to prohibit" and also means "complete respect and veneration", and because of this respect and veneration whatever special religious prohibitions are applicable to Makkah and its surrounding land are also included in it. For instance, whoever takes refuge in Haram is secured. It is not allowed to kill or take revenge from anyone in the Haram. Even hunting of animals and cutting of trees is not permitted in the precincts of Haram. These restrictions are enjoined in the verse وَمَن دَخَلَهُ كَانَ آمِنًا (and whoever enters there is secure - 3:97), while some of them have appeared in the beginning of Surah Ma’ idah. In addition, verse لَا تَقْتُلُوا الصَّيْدَ وَأَنتُمْ حُرُمٌ (do not kill game when, you are in Ihram - 5:95) also includes this subject.
One aspect of this prediction relates to the first addressees of the Quran (the Quraysh of Makkah) who were shown God’s signs in the earlier period of Islam through events such as the conquest of Makkah. The other aspect concerns the issue of the eternal guidance offered by the Quran. Thus the scientific evidence appearing in the modern period are also included in the wider scope of this prediction.
Uthmani text of the Madinah mushaf (King Fahd Complex). Translation: Saheeh International. Tafsir via Quran.com.